A New Era of Genetic Medicines

Transformative Cures.
Revolutionizing in vivo targeted genetic medicines with best-in-class cargo and precision delivery—bringing safer, more effective, and lasting cures to patients.
nChroma Bio is a pioneering biotechnology company advancing the development of both best-in-class cargo and targeted in vivo delivery technologies to realize the full potential of genetic medicines.
Our technologies harness the power of epigenetics and cell-specific protein delivery to tackle the most significant limitations of current gene therapies.

Our Platform

Building a Fully Integrated Product Engine

Epigenetic Editors

Illustration of Epigenetic Editors
  • Potential for one-time, lifelong cures
  • No cuts, nicks, or changes to patients' DNA sequence
  • Best-in-class potency at clinically relevant doses
  • Broad therapeutic potential (silencing, activation, 
and multiplexed gene regulation)
  • Reversible gene regulation

DLVR Particles

Illustration of DLVR Particles
  • Efficient delivery of multiple macromolecules, including RNPs for gene editing
  • Programmable for cell-specific targeting
  • Can leverage a proprietary library of human envelopes with novel tropism
  • In vitro validation of humanized particle

Our Programs

With over 250 million people living with HBV, there is a significant unmet need to develop lifelong cures.

Our lead development candidate, CRMA-1001, is an epigenetic editor in development as a potential functional cure for chronic hepatitis B and hepatitis D. Path to the clinic for CRMA-1001:

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Optimized epigenetic silencing construct to achieve deep and durable silencing with no off-target changes in expression

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Demonstrated best in class potency in pre-clinical HBV models and in NHPs using a surrogate target

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Currently in CTA-enabling studies

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Delivering cures in the clinic

Our Team

World-class Team at the Forefront of Genetic Medicine

Leadership

Jeffrey Walsh
Chief Executive Officer
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Jenny Marlowe, PhD
Chief Development Officer
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Melissa Bonner, PhD
Chief Scientific Officer
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Noah Goodman
Chief Business Officer
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Lisa McGrath
Chief People Officer
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Padma Malyala
Senior Vice President, Technical Development
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Archie Mathura
Vice President, Finance & Operations
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Board of Directors

Jeff Marrazzo (Chair)
Independent Board Member
Jess Alston, PhD
F-Prime Capital
Kevin Bitterman, PhD
Atlas Venture
Thomas Cahill, MD, PhD
Newpath Partners
Bihua Chen
Cormorant Asset Management
Michael A. Kelly
Sentry Hill Partners, LLC
Melissa J. Moore, PhD
Independent Board Member
Jeffrey Walsh
nChroma Bio CEO

Founders

Luke Gilbert, PhD
University of California, San Francisco
Keith Joung, MD, PhD
Arena Bioworks
David Liu, PhD
Broad Institute of MIT and Harvard University
Angelo Lombardo, PhD
San Raffaele Scientific Institute for Gene Therapy and Vita-Salute San Raffaele University
Luigi Naldini, MD, PhD
San Raffaele Telethon Institute for Gene Therapy
Jonathan Weissman, PhD
Whitehead Institute and MIT

Investors

Partners in Our Mission

5AM Ventures logoAlexandria Venture Investments logoArch Venture Partners logoAtlas Venture logoCasdin Capital logoCormorant Asset Management logoDCVC Bio logoF-Prime logoGV logoJanus Henderson Investors logoMubadala logoNewpath PartnersOmega Funds logoSixth Street logoSofinnova Partners logoT. Rowe Price logoWellington Manaagement logo